Furthermore, a 3-day test with Synacthen Depot may be used to differentiate between primary and secondary adrenocortical insufficiency.Ĭhildren: An intravenous dose of 250micrograms/1.73m 2 body surface area has been suggested.

Where the 30-minute test has yielded inconclusive results, or where it is desired to determine the functional reserve of the adrenal cortex, a 5-hour test can be performed with Synacthen Depot (see separate Summary of Product Characteristics). if the value 30 minutes after injection is >500 nmol/litre (180 micrograms/litre), adrenocortical function is regarded as normal.Īll the plasma samples should be stored in a refrigerator until plasma cortisol level estimation. Adrenocortical function can be regarded as normal if the post-injection rise in plasma cortisol concentration increases by 200 nmol/litre (70 micrograms/litre), i.e. The 30-minute Synacthen diagnostic test: This test is based on measurement of the plasma cortisol concentration immediately before and exactly 30 minutes after an intramuscular or intravenous injection of 250 micrograms (1ml) Synacthen. Date of first authorisation/renewal of the authorisationĪdults: This preparation of Synacthen is intended for administration for diagnostic purposes only as a single intramuscular or intravenous dose it is not to be used for repeated therapeutic administration.

6.6 Special precautions for disposal and other handling.

4.7 Effects on ability to drive and use machines.

4.5 Interaction with other medicinal products and other forms of interaction.

4.4 Special warnings and precautions for use.

4.2 Posology and method of administration.

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Synacthen atc4